Curr Opin Immunol. 1992 Jun;4(3):271-6. doi: 10.1016/0952-7915(92)90076-q.


In the past year there have been significant advances in understanding the role of interleukin-2. Its role in the activation of T cells by antigen-presenting cells, the structure-activity relationships between interleukin-2 and its receptor and the subsequent signaling have all become clearer. The creation of mice with a specific defect in the interleukin-2 gene has given us a clearer idea of its role in vivo. Recent studies also suggest that interleukin-2 may finally find a role in immunotherapy.

Publication types

  • Review

MeSH terms

  • Animals
  • Gene Expression
  • Humans
  • Immunosuppression Therapy
  • Immunotoxins / pharmacology
  • Interleukin-2 / chemistry
  • Interleukin-2 / genetics
  • Interleukin-2 / physiology*
  • Receptors, Interleukin-2 / chemistry
  • Signal Transduction / immunology
  • Structure-Activity Relationship


  • Immunotoxins
  • Interleukin-2
  • Receptors, Interleukin-2