Curr Opin Immunol. 1992 Jun;4(3):321-6. doi: 10.1016/0952-7915(92)90083-q.


During the past year, the most striking progress in our understanding of interferon-gamma has been made in the elucidation of the three-dimensional structure of the molecule and in the analysis of the molecular structure and the functional domains of the interferon-gamma receptor. A greater insight into the molecular mechanisms of gene activation by interferon-gamma has been gained, and the immunoregulatory role of interferon-gamma has been better defined in studies dealing with its effects on B-cell function and with its production by the various T-cell subsets. Finally, the effects of interferon-gamma on intracellular parasites is an important aspect of interferon-gamma activity that is giving rise to several clinical trials.

Publication types

  • Review

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • Base Sequence
  • Consensus Sequence
  • Cytokines / physiology
  • Humans
  • Interferon-gamma / chemistry
  • Interferon-gamma / physiology*
  • Molecular Sequence Data
  • Receptors, Interferon / chemistry
  • Structure-Activity Relationship
  • T-Lymphocytes, Helper-Inducer / immunology


  • Cytokines
  • Receptors, Interferon
  • Interferon-gamma