The rat brain postsynaptic density fraction contains a homolog of the Drosophila discs-large tumor suppressor protein

Neuron. 1992 Nov;9(5):929-42. doi: 10.1016/0896-6273(92)90245-9.


In CNS synapses, the synaptic junctional complex with associated postsynaptic density is presumed to contain proteins responsible for adhesion between pre- and postsynaptic membranes and for postsynaptic signal transduction. We have found that a prominent, brain-specific protein (PSD-95) enriched in the postsynaptic density fraction from rat brain is highly similar to the Drosophila lethal(1)discs-large-1 (dlg) tumor suppressor protein. The dlg protein is associated with septate junctions in developing flies and contains a guanylate kinase domain that is required for normal control of cell division. The sequence similarity between dlg and PSD-95 suggests that molecular mechanisms critical for growth control in developing organisms may also regulate synapse formation, stabilization, or function in the adult brain.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Base Sequence
  • Brain / embryology
  • Brain / growth & development
  • Brain / physiology
  • Brain Chemistry*
  • DNA / chemistry
  • Dendrites / chemistry
  • Disks Large Homolog 4 Protein
  • Drosophila Proteins*
  • Gene Expression
  • Insect Hormones / chemistry*
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Molecular Sequence Data
  • Nerve Tissue Proteins / chemistry*
  • Nerve Tissue Proteins / genetics
  • RNA, Messenger / analysis
  • Rats
  • Sequence Homology, Amino Acid
  • Synapses / chemistry*
  • Synapses / physiology
  • Tissue Distribution
  • Tumor Suppressor Proteins*


  • Disks Large Homolog 4 Protein
  • Dlg4 protein, rat
  • Drosophila Proteins
  • Insect Hormones
  • Intracellular Signaling Peptides and Proteins
  • Membrane Proteins
  • Nerve Tissue Proteins
  • RNA, Messenger
  • Tumor Suppressor Proteins
  • postsynaptic density proteins
  • dlg1 protein, Drosophila
  • DNA

Associated data

  • GENBANK/M96853