Abstract
Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Amino Acid Sequence
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Animals
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Biological Transport / physiology
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Carrier Proteins / chemistry*
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Humans
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Membrane Proteins / chemistry*
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Molecular Sequence Data
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Sequence Alignment
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Sequence Homology, Amino Acid
Substances
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Carrier Proteins
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Membrane Proteins