Membrane transport proteins: implications of sequence comparisons

Curr Opin Cell Biol. 1992 Aug;4(4):684-95. doi: 10.1016/0955-0674(92)90090-y.

Abstract

Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Biological Transport / physiology
  • Carrier Proteins / chemistry*
  • Humans
  • Membrane Proteins / chemistry*
  • Molecular Sequence Data
  • Sequence Alignment
  • Sequence Homology, Amino Acid

Substances

  • Carrier Proteins
  • Membrane Proteins