Membrane transport proteins: implications of sequence comparisons

J K Griffith; M E Baker; D A Rouch; M G Page; R A Skurray; I T Paulsen; K F Chater; S A Baldwin; P J Henderson

doi:10.1016/0955-0674(92)90090-y

Membrane transport proteins: implications of sequence comparisons

Curr Opin Cell Biol. 1992 Aug;4(4):684-95. doi: 10.1016/0955-0674(92)90090-y.

Authors

J K Griffith¹, M E Baker, D A Rouch, M G Page, R A Skurray, I T Paulsen, K F Chater, S A Baldwin, P J Henderson

Affiliation

¹ University of New Mexico.

PMID: 1419050
DOI: 10.1016/0955-0674(92)90090-y

Abstract

Analyses of the sequences and structures of many transport proteins that differ in substrate specificity, direction of transport and mechanism of transport suggest that they form a family of related proteins. Their sequence similarities imply a common mechanism of action. This hypothesis provides an objective basis for examining their mechanisms of action and relationships to other transporters.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.
Review

MeSH terms

Amino Acid Sequence
Animals
Biological Transport / physiology
Carrier Proteins / chemistry*
Humans
Membrane Proteins / chemistry*
Molecular Sequence Data
Sequence Alignment
Sequence Homology, Amino Acid

Substances

Carrier Proteins
Membrane Proteins

Grant support

2-S06-GM08139-18/GM/NIGMS NIH HHS/United States