Regulation of cartilage and bone differentiation by bone morphogenetic proteins

Curr Opin Cell Biol. 1992 Oct;4(5):850-5. doi: 10.1016/0955-0674(92)90110-x.


Quantum advances have recently been made in the understanding of the regulation of cartilage and bone differentiation through the identification, purification, genetic cloning and expression of recombinant bone morphogenetic proteins. Bone morphogenetic proteins are a family of pleiotropic differentiation factors with actions on chemotaxis, mitosis, initiation and promotion of chondrogenic and osteogenic phenotypes. They bind extracellular matrix components, heparin and type IV collagen and initiate bone repair. The cascade of cartilage and bone differentiation consists of several continuous phases: initiation, promotion, maintenance and termination.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Bone Development / physiology*
  • Bone Morphogenetic Proteins
  • Cartilage / cytology*
  • Cell Differentiation
  • Growth Substances / metabolism*
  • Humans
  • Proteins / genetics
  • Proteins / metabolism*


  • Bone Morphogenetic Proteins
  • Growth Substances
  • Proteins