The expression of 5T4 antigen in colorectal and gastric carcinoma

Br J Cancer. 1992 Nov;66(5):867-9. doi: 10.1038/bjc.1992.375.


The expression of 5T4, an oncotrophoblast cell surface antigen was examined in 72 colorectal and 27 gastric carcinomas, with immunoperoxidase technique, on frozen sections. Highly significant association was found between 5T4 expression in the malignant cells and metastatic spread. The results suggest that the appearance of 5T4 molecules in cancer cells reflects a change which may contribute to the development of metastatic potential.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, Neoplasm / analysis*
  • Biomarkers, Tumor / analysis*
  • Colorectal Neoplasms / immunology*
  • Colorectal Neoplasms / pathology
  • Humans
  • Immunohistochemistry
  • Membrane Glycoproteins / analysis*
  • Neoplasm Staging
  • Stomach Neoplasms / immunology*
  • Stomach Neoplasms / pathology


  • Antigens, Neoplasm
  • Biomarkers, Tumor
  • Membrane Glycoproteins
  • trophoblastic glycoprotein 5T4, human