Bath-water compared with oral delivery of 8-methoxypsoralen PUVA therapy for chronic plaque psoriasis

Br J Dermatol. 1992 Oct;127(4):392-5. doi: 10.1111/j.1365-2133.1992.tb00460.x.

Abstract

Forty-four patients with chronic plaque psoriasis were randomly allocated to treatment with bath-water-delivered 8-methoxypsoralen (bath 8-MOP) or oral 8-methoxypsoralen (oral 8-MOP) PUVA therapy. There was a significant reduction in extent of the lesions and psoriasis area and severity index (PASI) after 20 treatments with each modality. There was a fourfold reduction in cumulative ultraviolet A (UVA) dose in the bath group. Side-effects of erythema and nausea were less with bath therapy.

Publication types

  • Clinical Trial
  • Clinical Trial, Phase IV
  • Comparative Study
  • Randomized Controlled Trial

MeSH terms

  • Administration, Oral
  • Administration, Topical
  • Adolescent
  • Adult
  • Baths*
  • Chronic Disease
  • Female
  • Humans
  • Male
  • Methoxsalen / administration & dosage*
  • Middle Aged
  • PUVA Therapy / methods*
  • Psoriasis / drug therapy*
  • Severity of Illness Index
  • Single-Blind Method

Substances

  • Methoxsalen