Follow up study of renal tubular dysfunction and mortality in residents of an area polluted with cadmium

Br J Ind Med. 1992 Oct;49(10):736-7. doi: 10.1136/oem.49.10.736.


A retrospective cohort study was conducted to investigate the association between cadmium induced renal tubular dysfunction and mortality. A total of 230 subjects aged 40 or older and living in a cadmium polluted area in Kosaka Town, Akita Prefecture, Japan, were studied at least once between 1975 and 1977 and again in 1990. Urinary beta 2-microglobulin and total amino nitrogen concentrations were significantly related to mortality from all causes in women. The finding supports the idea that cadmium induced kidney damage is a factor associated with mortality in a general population exposed to environmental cadmium.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cadmium Poisoning / mortality*
  • Cadmium Poisoning / physiopathology
  • Cohort Studies
  • Environmental Exposure / adverse effects*
  • Female
  • Humans
  • Japan / epidemiology
  • Kidney Diseases / mortality*
  • Kidney Diseases / physiopathology
  • Kidney Tubules / physiopathology*
  • Male
  • Middle Aged
  • Prospective Studies