Previous miscarriage and stillbirth as risk factors for other unfavourable outcomes in the next pregnancy

Br J Obstet Gynaecol. 1992 Oct;99(10):808-12. doi: 10.1111/j.1471-0528.1992.tb14411.x.


Objective: To look for associations between previous fetal loss and fetal malformation or low birthweight in a subsequent pregnancy.

Design: A case-control study with place of birth, time and sex matched controls.

Setting: 72 South American maternity hospitals.

Subjects: 18,534 malformed, 1150 non-malformed babies of low birthweight and 16,394 controls. All babies were from mothers with at least one previous pregnancy.

Main outcome measures: Frequency of stillbirths and miscarriages in the previous pregnancy and outcome of the index pregnancy.

Results: Multiple malformation, Down's syndrome, anencephaly, spina bifida, pes equinovarus, congenital dislocation of the hip and low birthweight are associated with previous fetal loss.

Conclusion: A miscarriage or a stillbirth in a previous pregnancy should be taken into account when the risk of malformations or low birthweight in a subsequent pregnancy is assessed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Spontaneous / complications*
  • Congenital Abnormalities / etiology
  • Female
  • Fetal Death
  • Hip Dislocation, Congenital / etiology
  • Humans
  • Infant, Low Birth Weight
  • Infant, Newborn
  • Male
  • Pregnancy
  • Pregnancy Outcome*
  • Risk Factors
  • Time Factors