Brain injury in the premature infant--current concepts of pathogenesis and prevention

Biol Neonate. 1992;62(4):231-42. doi: 10.1159/000243876.


Brain injury in the premature infant and, particularly, the prevention of that injury is an enormous problem. With modern neonatal intensive care, approximately 85% of very low birth weight infants survive, and of these survivals, approximately 5-15% exhibit major spastic motor deficit, grouped under the rubric, 'cerebral palsy', and an additional 25-50% exhibit less prominent developmental disabilities, particularly school failure.

Publication types

  • Review

MeSH terms

  • Brain Injuries / etiology*
  • Brain Injuries / pathology
  • Brain Injuries / prevention & control
  • Cerebral Hemorrhage / etiology
  • Cerebral Infarction / etiology
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Leukomalacia, Periventricular / etiology
  • Nervous System Diseases / etiology
  • Nervous System Diseases / pathology