Possible inspiratory off-switch neurones in the ventrolateral medulla of the cat

Neuroreport. 1992 Oct;3(10):933-6. doi: 10.1097/00001756-199210000-00029.


The location and axonal projection of a type of respiratory neurones (termed bIE neurones), which show burst firing at the time of phase transition from inspiration to expiration, were studied in Nembutal-anaesthetized, paralysed and artificially ventilated cats. The bIE neurones showed maximum firing at the sharp decline of inspiratory activity. All of the bIE neurones tested projected to medullary respiration-related areas of the ventral respiratory group (VRG), the dorsal respiratory group (DRG), and the Bötzinger complex (BOT). The bIE neurones were distributed in the dorso-medial border of the main assembly of respiratory neurones of the VRG and BOT. The possibility that these bIE neurones participate in inspiratory termination is discussed.

MeSH terms

  • Animals
  • Axons / physiology
  • Cats
  • Laryngeal Nerves / physiology
  • Medulla Oblongata / cytology
  • Medulla Oblongata / physiology*
  • Neurons / physiology*
  • Phrenic Nerve / drug effects
  • Respiration / physiology
  • Stereotaxic Techniques