Anaplastic thyroid carcinoma with prominent cardiac metastasis, accompanied by a marked leukocytosis with a neutrophilia and high GM-CSF level in serum

Intern Med. 1992 Sep;31(9):1107-11. doi: 10.2169/internalmedicine.31.1107.


Cardiac metastasis of thyroid carcinoma is extremely rare. We treated a case of anaplastic thyroid carcinoma with prominent cardiac metastasis. The 61-year-old male was admitted because of high fever. Investigations revealed a cardiac mass and anaplastic thyroid carcinoma. Resection of the cardiac mass revealed that it was metastasis from the thyroid carcinoma. After 4 months, he died in spite of intensive therapy. Marked leukocytosis was observed during the clinical course, and a concomitant increase of granulocyte macrophage-colony stimulating factor (GM-CSF) level was demonstrated in the sera. It was suggested that the high GM-CSF level in serum contributed to leukocytosis.

Publication types

  • Case Reports

MeSH terms

  • Carcinoma / secondary
  • Granulocyte-Macrophage Colony-Stimulating Factor / blood
  • Heart Neoplasms / secondary*
  • Humans
  • Leukocytosis / blood
  • Male
  • Middle Aged
  • Thyroid Neoplasms / pathology*


  • Granulocyte-Macrophage Colony-Stimulating Factor