Temazepam misuse in a group of injecting drug users

Br J Addict. 1992 Oct;87(10):1387-92. doi: 10.1111/j.1360-0443.1992.tb01918.x.


It is well recognized that many injecting drug users are poly-drug users. The intravenous use of Temazepam has become popular recently. In response to the ease of misuse, the pharmaceutical industry produced a formulation that would be as 'resistant' as possible to injecting. The preparation is a gel-filled formulation, one proprietary name being Temazepam Gelthix. General Practitioners have been encouraged to prescribe gel-filled capsules to potential drug misusers in order to reduce the harm Temazepam can cause by its misuse. This study of 23 Temazepam injectors shows that the group still find the gel-filled preparation readily injectable. It appears to be more problematic in causing medical complications including superficial thrombophlebitis, abscesses and deep venous thrombosis. Temazepam misuse can cause drug users to become more chaotic. The study group recognize this and suggest there should be stricter control on the supply of Temazepam to drug dependents. General Practitioners, who are the main source of Temazepam prescribing, require additional training in prescribing to drug users.

MeSH terms

  • Adult
  • Capsules
  • Dose-Response Relationship, Drug
  • Female
  • HIV Infections / transmission
  • Humans
  • Male
  • Risk Factors
  • Substance Abuse, Intravenous / etiology*
  • Substance Abuse, Intravenous / prevention & control
  • Temazepam* / adverse effects


  • Capsules
  • Temazepam