PROTEIN STRUCTURE RELATIONSHIPS REVEALED BY MUTATIONAL ANALYSIS

Science. 1964 Dec 18;146(3651):1593-4. doi: 10.1126/science.146.3651.1593.

Abstract

Studies of tryptophan synthetase A-protein mutants have shown a structural relationship between the positions of amino acid changes associated with forward mutations and second-site reverse mutations.

MeSH terms

  • Amino Acids*
  • Bacterial Proteins*
  • Chemical Phenomena*
  • Chemistry*
  • Escherichia coli*
  • Ligases*
  • Mutation*
  • Proteins*
  • Research*

Substances

  • Amino Acids
  • Bacterial Proteins
  • Proteins
  • Ligases