Host resistance and the immune system

Clin Geriatr Med. 1992 Nov;8(4):701-11.


Elderly persons are more susceptible and vulnerable to many infections compared with young adults. This phenomenon can be attributed to a decline in host defense mechanisms, particularly altered immune function. The effects of aging on T- and B-lymphocyte function; antigen-presenting cells, natural killer cells, and granulocytes; and organ-specific host resistance are discussed in this article.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Aged
  • Aging / immunology*
  • B-Lymphocytes / immunology
  • B-Lymphocytes / physiology
  • Humans
  • Immune System / physiology*
  • Immunity, Innate
  • Immunocompromised Host / physiology*
  • Infections / immunology*
  • Organ Specificity / immunology
  • T-Lymphocytes / physiology