Adhesion molecules are expressed in the human retina and choroid

Curr Eye Res. 1992:11 Suppl:153-9. doi: 10.3109/02713689208999526.


Immunoperoxidase staining of samples of normal human retina and choroid was performed to demonstrate selected adhesion molecules in vivo. Intercellular adhesion molecule-1 (ICAM-1), lymphocyte function-associated antigen-3 (LFA-3) and endothelial leucocyte adhesion molecule-1 (ELAM-1) were expressed on retinal vascular endothelium and ICAM-1 and ELAM-1 in the region of the external limiting membrane. The very late antigen-2 (VLA-2) was found around the retinal ganglion cells and in the inner and outer fibre layers. The endothelium on the choriocapillaris showed moderate staining of ICAM-1, and slight staining of LFA-3 and ELAM-1. The presence of these molecules in this distribution strongly suggests they have an important role in the pathogenesis of immunologically mediated ocular conditions.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antibodies, Monoclonal
  • Cell Adhesion Molecules / analysis*
  • Choroid / immunology*
  • Histocompatibility Antigens Class II / analysis
  • Humans
  • Immunoenzyme Techniques
  • Lymphocyte Function-Associated Antigen-1 / analysis
  • Retina / immunology*


  • Antibodies, Monoclonal
  • Cell Adhesion Molecules
  • Histocompatibility Antigens Class II
  • Lymphocyte Function-Associated Antigen-1