Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions

R A van Hogezand; H M Kennis; A van Schaik; J P Koopman; P A van Hees; J H van Tongeren

doi:10.1007/BF01740669

Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions

Eur J Clin Pharmacol. 1992;43(2):189-92. doi: 10.1007/BF01740669.

Authors

R A van Hogezand¹, H M Kennis, A van Schaik, J P Koopman, P A van Hees, J H van Tongeren

Affiliation

¹ Department of Medicine, St. Radboud Hospital, Nijmegen, The Netherlands.

PMID: 1425876
DOI: 10.1007/BF01740669

Abstract

After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid. In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 10(8) faecal dilution 44% were able to acetylate 5-aminosalicylic acid. We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.

MeSH terms

Acetylation
Aerobiosis
Aminosalicylic Acids / metabolism*
Anaerobiosis
Bacteria / metabolism*
Bacteriological Techniques
Feces / microbiology*
Humans
Mesalamine

Substances

Aminosalicylic Acids
Mesalamine