Isoflurane anesthesia is stereoselective

Eur J Pharmacol. 1992 Jul 7;217(2-3):215-6. doi: 10.1016/0014-2999(92)90875-5.


The anesthetic effects of the (+) and (-) isomers of isoflurane were determined in mice. Like the clinically important racemate, both isomers produced dose-dependent increases in anesthetic sleep time. A statistically significant (P less than 0.005, ANOVA) difference in the potencies of these isomers ((+) greater than (-)) was observed. To our knowledge, this is the first demonstration of a stereospecific action of a volatile anesthetic in vivo.

MeSH terms

  • Analysis of Variance
  • Anesthesia*
  • Animals
  • Injections, Intraperitoneal
  • Isoflurane* / administration & dosage
  • Male
  • Mice
  • Stereoisomerism


  • Isoflurane