Loss of transcription factor AP-1 DNA binding activity during lymphocyte aging in vivo

FEBS Lett. 1992 Nov 9;312(2-3):179-82. doi: 10.1016/0014-5793(92)80930-f.


The main feature of cellular senescence is cessation of cell proliferation. Protooncogene c-fos, which is required for the cell to enter into DNA synthesis, is repressed in senescent fibroblasts. Diminished expression of c-fos and impaired formation of AP-1, which is a complex of c-Fos and c-Jun proteins acting as a transcription factor, was found in lymphocytes derived from old (> 18 months) mice and stimulated with Con A. There were no differences in c-jun expression and formation of other transcription factors (AP-2 and AP-3) between lymphocytes isolated from old and young mice.

MeSH terms

  • Animals
  • Base Sequence
  • Cells, Cultured
  • Cellular Senescence / physiology*
  • Concanavalin A / pharmacology
  • DNA / metabolism*
  • Lymphocytes / cytology*
  • Lymphocytes / metabolism
  • Mice
  • Molecular Sequence Data
  • Protein Binding
  • Proto-Oncogene Proteins c-fos / genetics
  • Proto-Oncogene Proteins c-jun / genetics
  • Proto-Oncogene Proteins c-jun / metabolism*
  • RNA, Messenger / genetics


  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • RNA, Messenger
  • Concanavalin A
  • DNA