Intrauterine insemination after ovarian stimulation as a treatment for subfertility because of subnormal semen: a prospective randomized controlled trial

Fertil Steril. 1992 Nov;58(5):995-9. doi: 10.1016/s0015-0282(16)55449-1.


Objective: To determine whether intrauterine insemination (IUI) after ovarian stimulation with human menopausal gonadotropin (hMG) gives a better pregnancy rate (PR) than natural intercourse in couples with subfertility because of subnormal semen.

Design: Prospective randomized controlled trial.

Setting: University based subfertility clinic.

Patients: Couples with subnormal semen as the only identifiable cause of subfertility.

Interventions: In control cycles, the couples had natural intercourse. In IUI cycles, IUI was performed after ovarian stimulation with hMG and human chorionic gonadotropin.

Main outcome measure: The clinical PRs and complications of IUI cycles and control cycles were compared.

Results: There were six clinical pregnancies in the 42 IUI cycles, whereas there was no clinical pregnancy in the 42 control cycles. The clinical PR in IUI cycles (14.3% per cycle) was significantly higher than that in control cycles (0%). Six patients (14.3%) developed moderate degree of ovarian hyperstimulation syndrome in IUI cycles.

Conclusion: Intrauterine insemination after ovarian stimulation with hMG is useful in treatment of subfertile couples with subnormal semen.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Chorionic Gonadotropin / therapeutic use*
  • Estradiol / blood
  • Female
  • Humans
  • Infertility, Male / therapy*
  • Insemination, Artificial, Homologous*
  • Male
  • Menotropins / therapeutic use*
  • Pregnancy
  • Prospective Studies
  • Semen / physiology*
  • Sperm Count
  • Sperm Motility
  • Spermatozoa / abnormalities


  • Chorionic Gonadotropin
  • Estradiol
  • Menotropins