Brain atrophy on computerized axial tomography scans: interaction of age, diabetes and general morbidity

Gerontology. 1992;38(5):285-91. doi: 10.1159/000213342.


We evaluated, retrospectively, the occurrence of brain atrophy in all patients (n = 416) with a brain CT scan performed during a 3-month period in 1989 at the Tampere University Central Hospital. Age, diabetes, hypertension, chronic cerebrovascular disorders and an increasing number of medications were associated with brain atrophy in the log-linear models. We suggest that the effect of various systemic medical disorders on the brain requires consideration when evaluating and assessing physiological ageing of the brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aging / pathology*
  • Atrophy / diagnostic imaging
  • Brain / diagnostic imaging
  • Brain / pathology*
  • Cerebrovascular Disorders / diagnostic imaging
  • Cerebrovascular Disorders / pathology*
  • Diabetes Mellitus / diagnostic imaging
  • Diabetes Mellitus / pathology*
  • Humans
  • Linear Models
  • Middle Aged
  • Retrospective Studies
  • Tomography, X-Ray Computed*