[Modeling of myocardial pathology in mice with the surgical methods]

Kardiologiia. 1977 Jun;17(6):125-8.
[Article in Russian]


A description of three operations on the heart in mice is presented: a supravalvular narrowing of the ascending aorta, banding of the apex of the heart, and ligation of the coronaries. These surgical interventions permit to obtain in mice a functional overloading and hypertrophy of the myocardium, a cardiac aneurysm and occlusive myocardial infarction.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Aorta, Thoracic / surgery
  • Cardiac Surgical Procedures
  • Cardiomegaly / etiology*
  • Coronary Vessels / surgery
  • Disease Models, Animal*
  • Heart Aneurysm / etiology*
  • Ligation
  • Male
  • Methods
  • Mice
  • Mice, Inbred Strains*
  • Myocardial Infarction / etiology*