Can Med Assoc J. 1965 Jun 12;92(24):1258-60.


The records of 147 patients who had pruritus and jaundice (11% of a series of 1262 patients with jaundice) were reviewed in an effort to delineate more clearly the etiology of jaundice associated with pruritus.Fifty-two had obstructive jaundice caused by neoplasm, 51 had obstructive jaundice not caused by neoplasm, 42 had pruritus associated with hepatogenous jaundice, and two had jaundice and pruritus associated with a lymphoma.Pruritus occurred in 17% of all patients with non-neoplastic obstructive jaundice and in 45% of patients with neoplastic obstructive jaundice. Hepatogenous jaundice was the cause of pruritus in almost one-third of the patients in this series-occurring in 20% of patients with infectious hepatitis and in 7% of patients with cirrhosis.This large series confirms the clinical impression that pruritus occurs most often in association with extrahepatic biliary obstruction, and as well re-emphasizes the common association of pruritus with hepatogenous jaundice.

MeSH terms

  • Bile Duct Neoplasms*
  • Cholelithiasis*
  • Diagnosis*
  • Gallbladder Neoplasms*
  • Hepatitis A*
  • Hepatitis*
  • Humans
  • Jaundice*
  • Jaundice, Obstructive*
  • Liver Cirrhosis*
  • Liver Neoplasms*
  • Pancreatic Neoplasms*
  • Pruritus*