alpha-Naphthoflavone activation of 6-hydroxymethylbenzo(alpha)pyrene synthetase

Cancer Res. 1975 Dec;35(12):3731-4.

Abstract

alpha-Naphthoflavone activates the aryl hydroxymethyl synthetase of both the microsomal membrane-bound and soluble enzymes of rat liver and rat lung. The enzyme catalyzes the hydroxymethylation of benzo(alpha)pyrene to the 6-hydroxymethyl derivative.

MeSH terms

  • Animals
  • Benzoflavones
  • Benzopyrenes
  • Enzyme Activation
  • Flavonoids / pharmacology*
  • Hydrogen-Ion Concentration
  • Hydroxymethyl and Formyl Transferases
  • Lung / ultrastructure
  • Membranes / metabolism
  • Microsomes / drug effects
  • Microsomes / enzymology*
  • Microsomes, Liver / enzymology
  • Rats
  • Transferases / metabolism*

Substances

  • Benzoflavones
  • Benzopyrenes
  • Flavonoids
  • alpha-naphthoflavone
  • Transferases
  • 6-hydroxymethylbenzo(alpha)pyrene synthetase
  • Hydroxymethyl and Formyl Transferases