Relationship between platelet monoamine oxidase B activity and alleles at the MAOB locus

J Neurochem. 1992 Dec;59(6):2063-6. doi: 10.1111/j.1471-4159.1992.tb10095.x.


Genetic variations in monoamine oxidase (MAO)-B activity have been proposed to have a contributory role in several neurologic and psychiatric diseases. Variations in activity could affect rates of degradation of exogenous amines, including toxins, precursors of toxins (like 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), or false transmitters, and of endogenous amines, such as neurotransmitters. In this study a highly polymorphic (GT)n repeat element was used to mark alleles at the MAOB locus. The MAOB allele status and levels of platelet MAO-B activity were determined for 41 control males. No correlation was noted between specific alleles and levels of MAO-B activity in this sample set. This suggests that the structural gene for MAOB is not usually the primary determinant of activity levels in platelets.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Alleles*
  • Base Sequence
  • Blood Platelets / enzymology*
  • Chromosome Mapping
  • Enzyme Activation
  • Genetic Variation
  • Humans
  • Male
  • Middle Aged
  • Molecular Sequence Data
  • Monoamine Oxidase / blood*
  • Monoamine Oxidase / genetics*
  • Polymorphism, Genetic


  • Monoamine Oxidase