99mTc human immunoglobulin scintigraphy--a reliable method to detect joint activity in rheumatoid arthritis

J Rheumatol. 1992 Sep;19(9):1371-6.


The ability of 99mtechnetium labelled nonspecific, polyclonal human immunoglobulin G (99mTc-IgG) scintigraphy to depict and quantify synovial inflammation was studied in 30 patients with rheumatoid arthritis (RA). All patients were injected with 350 MBq 99mTc-IgG and imaging was performed 4 h later. This resulted in excellent images of inflamed synovium. Scores for 99mTc-IgG joint scintigraphy correlated highly with scores for joint swelling and C-reactive protein levels, weakly with pain scores and not with radiographic scores of joint destruction. These results suggest that 99mTc-IgG joint scintigraphy may provide an objective test to detect synovitis and measure the activity of the disease.

MeSH terms

  • Adult
  • Aged
  • Arthritis, Rheumatoid / diagnostic imaging*
  • Arthritis, Rheumatoid / pathology
  • Arthritis, Rheumatoid / physiopathology
  • C-Reactive Protein / analysis
  • Female
  • Humans
  • Immunoglobulins*
  • Joints / diagnostic imaging*
  • Joints / pathology
  • Joints / physiopathology
  • Male
  • Middle Aged
  • Radionuclide Imaging
  • Synovial Membrane / diagnostic imaging
  • Synovial Membrane / pathology
  • Synovial Membrane / physiopathology
  • Synovitis / diagnosis
  • Synovitis / diagnostic imaging
  • Synovitis / pathology
  • Technetium*


  • Immunoglobulins
  • technetium Tc 99m immunoglobulin
  • Technetium
  • C-Reactive Protein