Discovery of a Novel Class of Orally Active, Non-Peptide Angiotensin II Antagonists

J Med Chem. 1992 Oct 2;35(20):3714-7. doi: 10.1021/jm00098a018.

MeSH terms

  • Administration, Oral
  • Angiotensin II / antagonists & inhibitors*
  • Animals
  • Biphenyl Compounds / administration & dosage
  • Biphenyl Compounds / chemical synthesis
  • Biphenyl Compounds / pharmacokinetics
  • Imidazoles / administration & dosage
  • Imidazoles / chemical synthesis
  • Imidazoles / pharmacokinetics
  • Losartan
  • Pyrimidines / administration & dosage
  • Pyrimidines / chemical synthesis*
  • Pyrimidines / pharmacokinetics
  • Rats
  • Rats, Inbred SHR
  • Rats, Sprague-Dawley
  • Structure-Activity Relationship
  • Tetrazoles / administration & dosage
  • Tetrazoles / chemical synthesis
  • Tetrazoles / pharmacokinetics

Substances

  • Biphenyl Compounds
  • Imidazoles
  • Pyrimidines
  • Tetrazoles
  • Angiotensin II
  • Losartan