Detection and assignment of the glucose signal in 1H NMR difference spectra of the human brain

Magn Reson Med. 1992 Sep;27(1):183-8. doi: 10.1002/mrm.1910270118.


The difference between 1H NMR spectra obtained during eu- and hyperglycemia exhibited well-resolved glucose peaks between 3 and 4 ppm as demonstrated by comparison with solution spectra. Estimated increases were consistent with recent 13C NMR quantitations of intracerebral glucose. Difference spectra were measured in 36-ml volumes from the human brain every 3 min.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Brain Chemistry*
  • Glucose / analysis*
  • Humans
  • Magnetic Resonance Spectroscopy / methods


  • Glucose