A second-generation linkage map of the human genome

Nature. 1992 Oct 29;359(6398):794-801. doi: 10.1038/359794a0.


A linkage map of the human genome has been constructed based on the segregation analysis of 814 newly characterized polymorphic loci containing short tracts of (C-A)n repeats in a panel of DNAs from eight large families. Statistical linkage analysis placed 813 of the markers into 23 linkage groups corresponding to the 22 autosomes and the X chromosome; 605 show a heterozygosity above 0.7 and 553 could be ordered with odds ratios above 1,000:1. The distance spanned corresponds to approximately 90% of the estimated length of the human genome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosome Mapping
  • Chromosomes, Human*
  • DNA / genetics
  • Gene Library
  • Genetic Linkage*
  • Genetic Markers
  • Genome, Human*
  • Genotype
  • Heterozygote
  • Humans
  • Polymerase Chain Reaction
  • Repetitive Sequences, Nucleic Acid


  • Genetic Markers
  • DNA