Glyburide-induced cholestatic hepatitis and liver failure. Case-report and review of the literature

Neth J Med. 1992 Jun;40(5-6):305-7.


As sulphonylurea derivatives are used ubiquitously, the possibility that they may cause liver disease deserves attention. In contrast to the known pattern of reversible parenchymal liver disease due to sulphonylurea derivatives, we describe a fatal case of glyburide-induced cholestatic hepatitis with liver failure.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Aged
  • Chemical and Drug Induced Liver Injury / etiology*
  • Cholestasis / chemically induced*
  • Female
  • Glyburide / adverse effects*
  • Humans


  • Glyburide