Plasma levels of the anaphylatoxins C3a and C4a in patients with IgA nephropathy/Henoch-Schönlein nephritis

Nephron. 1992;62(1):22-6. doi: 10.1159/000186989.


Measurements of plasma anaphylatoxins C3a and C4a were carried out as an indicator of in vivo complement activation in 46 patients suffering from IgA nephropathy/Henoch-Schönlein nephritis. There was a significant correlation between plasma levels of C4a and plasma creatinine and urea. We also found a significant correlation of plasma levels of C3a with plasma creatinine. We propose that the measurement of anaphylatoxin levels provides a sensitive indicator of in vivo complement activation and may serve as an additional method for monitoring the progress of disease in these patients.

MeSH terms

  • Adult
  • Circadian Rhythm
  • Complement C3a / analysis*
  • Complement C4a / analysis*
  • Creatinine / blood
  • Female
  • Glomerulonephritis, IGA / blood*
  • Humans
  • IgA Vasculitis / blood
  • IgA Vasculitis / complications
  • Male
  • Middle Aged
  • Nephritis / blood*
  • Nephritis / etiology
  • Proteinuria / blood
  • Urea / blood


  • Complement C3a
  • Complement C4a
  • Urea
  • Creatinine