Marchiafava-Bignami disease: serial changes in corpus callosum on MRI

Neuroradiology. 1992;34(6):480-2. doi: 10.1007/BF00598954.


Serial MRI findings of changes in corpus callosum lesions in two cases of Marchiafava-Bignami disease are presented. In both, MRI displayed diffuse swelling of the corpus callosum in the acute stage, thought to represent oedema and demyelination. In the chronic stage, in addition to atrophy of the corpus callosum with presumed focal necrosis, previously undescribed focal hypointensity on T2-weighted images, of unknown cause, was observed in the corpus callosum.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcoholism / complications*
  • Alcoholism / pathology
  • Alcoholism / rehabilitation
  • Brain Damage, Chronic / diagnosis*
  • Brain Damage, Chronic / pathology
  • Corpus Callosum / pathology*
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Nerve Degeneration / physiology*
  • Neurologic Examination
  • Substance-Related Disorders / diagnosis*
  • Substance-Related Disorders / pathology