Obstet Gynecol Clin North Am. 1992 Sep;19(3):497-510.


Metronidazole has proven to be a useful and inexpensive antibiotic for the treatment of T. vaginalis and bacterial vaginosis. Few alternatives exist for these two specific indications, and metronidazole will continue to play a primary role in therapy. Oral metronidazole continues to be a very inexpensive alternative to oral vancomycin for the treatment of C. difficile-induced pseudomembranous colitis. For the treatment of moderate to severe mixed aerobic/anaerobic pelvic infections, metronidazole should be considered secondarily in patients who have failed other multiple- or single-drug regimens or in patients who are infected. with anaerobic organisms resistant to other commonly used agents including clindamycin, cefoxitin, cefotetan, or ampicillin/sulbactam. Metronidazole is not a first line drug of choice for antibiotic prophylaxis in obstetric and gynecologic patients.

Publication types

  • Review

MeSH terms

  • Bacterial Infections / drug therapy*
  • Costs and Cost Analysis
  • Drug Interactions
  • Drug Resistance, Microbial
  • Enterocolitis, Pseudomembranous / drug therapy
  • Female
  • Genital Diseases, Female / drug therapy*
  • Humans
  • Metronidazole* / adverse effects
  • Metronidazole* / chemistry
  • Metronidazole* / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Parasitic / drug therapy*
  • Trichomonas Vaginitis / drug therapy
  • Vaginosis, Bacterial / drug therapy


  • Metronidazole