Delivery of micronized budesonide suspension by metered dose inhaler and jet nebulizer into a neonatal ventilator circuit

Pediatr Pulmonol. 1992 Jul;13(3):172-5. doi: 10.1002/ppul.1950130309.


We compared the delivery of a micronized suspension of budesonide by a metered dose inhaler (MDI) with two different spacers (Aerochamber and Aerovent) and by two jet nebulizers (MAD2 and Ultravent) to a ventilated neonatal test-lung using a standard neonatal ventilator circuit. The combination of MDI and Aerochamber was significantly better at delivering budesonide to a filter in front of the test lung (14.2% of aerosolized dose) than were either the MDI and Aerovent (3.6%) or the Ultravent or MAD2 jet nebulizers (0.02% and 0.68% of initial reservoir dose). Of the droplets emerging from the MDI, Aerochamber, and ET tube, 18% of the initial dose was in droplets less than 4.7 microns. Assuming that the test-lung model accurately reflects in vivo deposition, the combination of MDI and Aerochamber appears to be an extremely effective way of delivering budesonide aerosol to ventilated newborn infants.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aerosols
  • Bronchodilator Agents / administration & dosage*
  • Budesonide
  • Humans
  • Infant, Newborn*
  • Models, Biological
  • Nebulizers and Vaporizers*
  • Pregnenediones / administration & dosage*
  • Suspensions
  • Ventilators, Mechanical


  • Aerosols
  • Bronchodilator Agents
  • Pregnenediones
  • Suspensions
  • Budesonide