Glycinergic interventions potentiate the ability of MK 801 to raise the threshold voltage for tonic hindlimb extension in mice

Pharmacol Biochem Behav. 1992 Oct;43(2):609-12. doi: 10.1016/0091-3057(92)90198-o.

Abstract

Milacemide, an acylated prodrug of glycine, was able to increase the efficacy with which [+]-5-methyl-10,11-dihydro-5h-dibenzo[a,d]cyclohepten-5,10-imine meleate (MK 801) antagonized the electrical precipitation of seizures in mice. The mechanism of milacemide's potentiation of MK 801's antiseizure efficacy in intact mice is unclear; however, a glycine agonist selective for the strychnine-insensitive site on the NMDA receptor complex was also able to potentiate MK 801. The exciting possibility exists that an exogenous glycinergic intervention can potentiate NMDA-mediated neural transmission in intact animals.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Acetamides / pharmacology
  • Animals
  • Behavior, Animal / drug effects*
  • Cycloserine / pharmacology
  • Dizocilpine Maleate / pharmacology*
  • Dose-Response Relationship, Drug
  • Drug Synergism
  • Electric Stimulation
  • Electroshock
  • Glycine / physiology*
  • Hindlimb / physiology
  • Male
  • Mice
  • Monoamine Oxidase Inhibitors / pharmacology
  • Reflex / drug effects*

Substances

  • Acetamides
  • Monoamine Oxidase Inhibitors
  • milacemide
  • Dizocilpine Maleate
  • Cycloserine
  • Glycine