Effects of stress and blood type on cortisol and VLDL toxicity preventing activity

Psychosom Med. Sep-Oct 1992;54(5):612-9. doi: 10.1097/00006842-199209000-00008.


Past research has associated ABO blood type and mental stress with cardiovascular risk. We studied the effects of blood type (A vs. O) coupled with a mirror drawing stressor on very low density lipoprotein toxicity-preventing activity (TxPA) and plasma cortisol levels. Exposure to the stressor significantly decreased TxPA and increased cortisol for the total group of 25 older adult males. However, the stress response patterns of the 15 blood type A males were different from those of the 10 type O subjects. The blood type A group had higher initial levels of TxPA and cortisol as well as quicker stress recovery rates than the type O group. ABO blood type may be an important behavioral hematologic variable to assess in studies concerning biochemical stress response or cardiovascular risk.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • ABO Blood-Group System* / genetics
  • Aged
  • Cardiovascular Diseases / etiology
  • Health Status
  • Humans
  • Hydrocortisone / blood*
  • Lipoproteins, VLDL / blood*
  • Male
  • Middle Aged
  • Risk Factors
  • Sex Factors
  • Stress, Psychological / blood*
  • Type A Personality


  • ABO Blood-Group System
  • Lipoproteins, VLDL
  • Hydrocortisone