Abstract
Light microscopy immunohistochemical techniques were used to examine the distribution of glutamine synthetase in rat brain. Glutamine synthetase was found to be localized in the glial cells. Neuronal cell bodies, endothelial cells, and choroid epithelium contained no enzyme. The findings indicate that glia have a crucial role in glutamic acid, gamma-aminobutyric acid, and ammonia metabolism in brain.
Publication types
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Ammonia / metabolism
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Animals
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Brain / enzymology*
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Glutamate-Ammonia Ligase / metabolism*
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Glutamates / metabolism
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Immunoenzyme Techniques
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Neuroglia / enzymology*
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Neuroglia / metabolism
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Rats
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gamma-Aminobutyric Acid / metabolism
Substances
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Glutamates
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gamma-Aminobutyric Acid
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Ammonia
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Glutamate-Ammonia Ligase