Signal-averaging is an emerging new application of the ambulatory ECG. Whereas real-time signal-averaging of the high-resolution ECG has led to the measurement of abnormal QRS complex parameters and to the detection of ventricular late potentials in patients with a history of ventricular tachycardia or fibrillation at increased risk of an arrhythmic event, similar measurements can also be derived from ambulatory ECG tape recordings. This review describes the technical differences between real-time and ambulatory high-resolution ECG signal-averaging, and the early clinical studies that correlated measured QRS complex parameters and defined the agreement of late potential detection with the two technologies. Although there appears to be a promising cost-effective benefit from ambulatory ECG signal-averaging, limitations imposed by the technical differences must be recognized, and additional investigation is needed to define the appropriate clinical use and criteria for best diagnostic and prognostic value.