Guar gum in insulin-dependent diabetes: effects on glycemic control and serum lipoproteins

Am J Clin Nutr. 1992 Dec;56(6):1056-60. doi: 10.1093/ajcn/56.6.1056.

Abstract

We examined the effect of guar gum on glycemic control and serum lipid and lipoprotein profiles in mildly hypercholesterolemic patients with insulin-dependent diabetes. The study was done in a randomized, double-blind fashion with either guar gum or placebo added to the diet four times per day for 6 wk each. Fasting blood glucose and hemoglobin A1c decreased significantly during the guar-gum diet, whereas the diurnal glucose profile was unchanged. In addition, serum low-density-lipoprotein (LDL) cholesterol decreased by 20% and the ratio of LDL cholesterol to high-density-lipoprotein cholesterol by 28% during guar-gum therapy. No changes were seen in the placebo group. In conclusion, guar gum can improve glycemic control and decrease serum LDL-cholesterol concentrations in mildly hypercholesterolemic insulin-dependent diabetic patients and thus reduce risk factors for both micro- and macroangiopathic complications.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / metabolism*
  • Cholesterol, HDL / blood
  • Cholesterol, LDL / blood
  • Diabetes Mellitus, Type 1 / blood
  • Diabetes Mellitus, Type 1 / drug therapy*
  • Diet
  • Double-Blind Method
  • Energy Intake
  • Galactans / therapeutic use*
  • Glycated Hemoglobin A / metabolism
  • Humans
  • Lipoproteins / blood*
  • Mannans / therapeutic use*
  • Plant Gums

Substances

  • Blood Glucose
  • Cholesterol, HDL
  • Cholesterol, LDL
  • Galactans
  • Glycated Hemoglobin A
  • Lipoproteins
  • Mannans
  • Plant Gums
  • guar gum