Nonimmune Hydrops Fetalis Associated With Maternal Infection With Syphilis

Am J Obstet Gynecol. 1992 Jul;167(1):56-8. doi: 10.1016/s0002-9378(11)91625-1.


Intrauterine infection with syphilis was diagnosed by reactive maternal serologic studies, ultrasonographic findings, and exclusion of other causes in three hydropic fetuses at 31, 34, and 35 weeks' gestation. With penicillin therapy and preterm delivery all infants survived through the perinatal period. Intrauterine infection that follows syphilis is a potentially treatable cause of nonimmune hydrops.

MeSH terms

  • Adolescent
  • Adult
  • Female
  • Humans
  • Hydrops Fetalis / diagnostic imaging
  • Hydrops Fetalis / drug therapy
  • Hydrops Fetalis / etiology*
  • Infant, Newborn
  • Penicillins / therapeutic use
  • Pregnancy
  • Pregnancy Complications, Infectious*
  • Syphilis / complications*
  • Ultrasonography, Prenatal


  • Penicillins