Local anaesthetic: does it really reduce the pain of insertion of all sizes of venous cannula?

Anaesthesia. 1992 Oct;47(10):890-1. doi: 10.1111/j.1365-2044.1992.tb03157.x.


A recent study performed in this department showed that a subcutaneous injection of local anaesthetic was significantly less painful than the insertion of a 22-gauge venous cannula. However, our colleagues remained sceptical that local anaesthetic infiltration would eliminate the pain of cannulation. Consequently a further study was undertaken to compare the pain of cannulation with and without the use of local anaesthetic. The results show that pain of cannulation is significantly (p < 0.003) reduced after subcutaneous infiltration with 1% lignocaine when compared to cannulation without local infiltration. Persistent discomfort at the site of cannulation was eliminated by the use of local anaesthetic.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anesthesia, Local*
  • Catheterization, Peripheral / adverse effects*
  • Catheterization, Peripheral / instrumentation
  • Female
  • Humans
  • Injections, Subcutaneous
  • Lidocaine* / administration & dosage
  • Male
  • Middle Aged
  • Pain / prevention & control*


  • Lidocaine