Serum anti-SS-B/La and IgA rheumatoid factor are markers of salivary gland disease activity in primary Sjögren's syndrome

Arthritis Rheum. 1992 Nov;35(11):1368-72. doi: 10.1002/art.1780351119.


Objective: To identify serologic markers of salivary gland disease activity in 43 patients with primary Sjögren's syndrome.

Methods: Comparison of salivary gland biopsies (focus scores) and flow rates with serum concentrations of IgA and IgM rheumatoid factor (RF), total serum IgG, serum anti-SS-B/La antibodies, and the erythrocyte sedimentation rate.

Results: Serum anti-SS-B/La antibody levels correlated with focus scores (rs = 0.477, P < 0.0025). Serum IgA-RF concentrations correlated inversely with stimulated parotid gland salivary flow rates (rs = -0.394, P < 0.01).

Conclusion: Measuring serum levels of anti-SS-B/La and IgA-RF would be useful when monitoring salivary responses in therapeutic trials, especially in patients with minimal salivary function.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Antinuclear / analysis*
  • Biomarkers
  • Female
  • Humans
  • Immunoglobulin A / analysis*
  • Immunoglobulin M / analysis
  • Male
  • Middle Aged
  • Rheumatoid Factor / analysis*
  • Salivary Gland Diseases / immunology*
  • Salivary Gland Diseases / physiopathology
  • Sjogren's Syndrome / immunology*
  • Sjogren's Syndrome / physiopathology


  • Antibodies, Antinuclear
  • Biomarkers
  • Immunoglobulin A
  • Immunoglobulin M
  • SS-B antibodies
  • Rheumatoid Factor