Suppression of renal disease and arthritis, and prolongation of survival in MRL-lpr mice treated with an extract of Tripterygium wilfordii Hook f

Arthritis Rheum. 1992 Nov;35(11):1381-6. doi: 10.1002/art.1780351122.


Objective: Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis.

Methods: Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks.

Results: Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice.

Conclusion: TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-lpr/lpr mice.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Arthritis / immunology
  • Arthritis / pathology
  • Arthritis / prevention & control*
  • Female
  • Hindlimb
  • Joints / pathology
  • Kidney / pathology
  • Kidney Diseases / immunology
  • Kidney Diseases / pathology
  • Kidney Diseases / prevention & control*
  • Lupus Erythematosus, Systemic / complications*
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / mortality
  • Lymph Nodes / pathology
  • Mice
  • Mice, Mutant Strains*
  • Plant Extracts / pharmacology*
  • Proteinuria / prevention & control
  • Survival Analysis


  • Plant Extracts