Abstract
Objective:
Treatment of MRL-lpr/lpr mice with Tripterygium wilfordii Hook f (TWHf) to evaluate its effects on mortality, renal disease, and arthritis.
Methods:
Mice were fed water (group A, control), TWHf (group B), or first water and then TWHf (group C) from age 7 weeks until age 21 weeks.
Results:
Arthritis and glomerulonephritis were decreased in groups B and C mice, and survival was increased in group B mice.
Conclusion:
TWHf decreases the mortality rate, and severity of glomerulonephritis and arthritis in MRL-lpr/lpr mice.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Arthritis / immunology
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Arthritis / pathology
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Arthritis / prevention & control*
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Female
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Hindlimb
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Joints / pathology
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Kidney / pathology
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Kidney Diseases / immunology
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Kidney Diseases / pathology
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Kidney Diseases / prevention & control*
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Lupus Erythematosus, Systemic / complications*
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Lupus Erythematosus, Systemic / genetics
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Lupus Erythematosus, Systemic / mortality
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Lymph Nodes / pathology
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Mice
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Mice, Mutant Strains*
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Plant Extracts / pharmacology*
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Proteinuria / prevention & control
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Survival Analysis