Inhibitors of prostaglandin biosynthesis from Dalbergia odorifera

Chem Pharm Bull (Tokyo). 1992 Sep;40(9):2452-7. doi: 10.1248/cpb.40.2452.

Abstract

The root heartwood of Dalbergia odorifera T. Chen (Leguminosae) is a Chinese medicinal drug (Japanese name koshinko) used for a stagnant blood syndrome (stagnation of disordered blood; Japanese, oketsu). In addition to 10 known compounds, five new phenolic compounds, isomucronustyrene and hydroxyobtustyrene (cinnamylphenols), (+)-isoduartin (isoflavan), odoriflavene (isoflav-3-ene) and (-)-odoricarpan (pterocarpan) were isolated and their structures were elucidated on the basis of chemical and spectroscopic methods. Of the fifteen compounds isolated, cinnamylphenols, isoflavans, isoflavene and benzoic acid derivative significantly inhibited prostaglandin biosynthesis as well as platelet aggregation induced by arachidonic acid.

MeSH terms

  • Cyclooxygenase Inhibitors / isolation & purification*
  • Cyclooxygenase Inhibitors / pharmacology
  • Humans
  • In Vitro Techniques
  • Medicine, East Asian Traditional*
  • Plants, Medicinal / chemistry*
  • Platelet Aggregation / drug effects
  • Platelet Aggregation Inhibitors / pharmacology
  • Prostaglandin Antagonists

Substances

  • Cyclooxygenase Inhibitors
  • Platelet Aggregation Inhibitors
  • Prostaglandin Antagonists