Sexual dysfunction and psychological distress in methadone maintenance

Int J Addict. 1992 Nov;27(11):1325-34. doi: 10.3109/10826089209047354.


We administered the Derogatis Sexual Functioning Inventory to 25 methadone maintenance patients who had been on a stable dose of methadone for at least 2 months, and obtained ratings of depression and anxiety, levels of sex hormones, and liver function tests. Five subjects with significantly lower Global Sexual Satisfaction Index scores (p < .0001) had more psychological symptoms, higher methadone doses, poorer body image, and less sexual drive and satisfaction, but normal fund of sexual information and lifetime experience. Sexual dysfunction among methadone maintenance patients may be due to coexisting psychiatric problems rather than caused by opiates. Methadone patients presenting with sexual dysfunction should receive psychiatric evaluation.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Adult
  • Anxiety Disorders / chemically induced
  • Depressive Disorder / chemically induced*
  • Female
  • Humans
  • Hyperprolactinemia / chemically induced
  • Male
  • Methadone*
  • Middle Aged
  • Sexual Dysfunction, Physiological / chemically induced*
  • Substance-Related Disorders / psychology*


  • Methadone