Effects of estrogen on vein grafts

J Cardiovasc Surg (Torino). 1992 Sep-Oct;33(5):579-84.

Abstract

The effect of estrogen on veins was evaluated in vitro and in vivo in three species. 17 beta-estradiol did not significantly alter 3H-thymidine uptake in vitro in segments from either canine femoral or human saphenous veins. In vivo in a rabbit carotid vein graft model, 17 beta-estradiol administration did not affect the development of intimal hyperplasia but was associated with a higher rate of graft thrombosis. These data suggest that the effects of estrogen on veins differs from the effects reported in arteries. These differences were seen both in vitro in veins taken from their normal location and in vivo in veins placed in the arterial circulation.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Animals
  • Disease Models, Animal
  • Dogs
  • Drug Evaluation, Preclinical
  • Endothelium, Vascular / drug effects
  • Endothelium, Vascular / pathology
  • Estradiol / adverse effects
  • Estradiol / pharmacology*
  • Evaluation Studies as Topic
  • Female
  • Femoral Vein / drug effects*
  • Femoral Vein / transplantation
  • Graft Occlusion, Vascular / chemically induced
  • Graft Occlusion, Vascular / epidemiology
  • Humans
  • Hyperplasia
  • Injections, Subcutaneous
  • Male
  • Middle Aged
  • Rabbits
  • Saphenous Vein / drug effects*
  • Saphenous Vein / transplantation
  • Thymidine / pharmacokinetics

Substances

  • Estradiol
  • Thymidine