Allergenicity and nutritional adequacy of soy protein formulas

J Pediatr. 1992 Nov;121(5 Pt 2):S21-8. doi: 10.1016/s0022-3476(05)81402-7.


Soy protein formulas are used for different conditions, including cow milk protein allergy, lactose and galactose intolerance, and severe gastroenteritis. Feeding soy protein formulas to normal term infants is associated with normal growth, normal protein nutritional status, and normal bone mineralization. Recent studies of infants fed soy protein formulas exclusively during the first months of life revealed no immunologic abnormality; however, the use of such formulas for management of cow milk protein allergy and for prevention of atopy is controversial. Although in the past decade many studies have stressed soy allergenicity, soy allergenicity has been confirmed by the challenge test in only a few studies. In this article we review the studies dealing with the allergenicity of soy protein formulas. We also present our own data on their use in the prevention and management of cow milk protein allergy.

Publication types

  • Review

MeSH terms

  • Animals
  • Child, Preschool
  • Dermatitis, Atopic / immunology
  • Dermatitis, Atopic / prevention & control
  • Food Hypersensitivity / immunology
  • Food Hypersensitivity / prevention & control
  • Humans
  • Infant
  • Infant Food*
  • Infant Nutrition Disorders / immunology
  • Infant, Newborn
  • Milk Hypersensitivity / immunology
  • Milk Hypersensitivity / prevention & control
  • Nutritive Value
  • Plant Proteins, Dietary* / adverse effects
  • Plant Proteins, Dietary* / analysis
  • Plant Proteins, Dietary* / immunology
  • Plant Proteins, Dietary* / therapeutic use
  • Soybean Proteins


  • Plant Proteins, Dietary
  • Soybean Proteins