Treatment of peripheral tissue ischemia with topical nitroglycerin ointment in neonates

J Pediatr. 1992 Dec;121(6):980-3. doi: 10.1016/s0022-3476(05)80356-7.


Four neonates had resolution of peripheral tissue ischemia after the application of 2% nitroglycerin ointment. A dosage of 4 mm nitroglycerin ointment per kilogram of body weight was applied to two patients with ischemia caused by vasospasm from indwelling radial artery catheterization and to two patients with ischemia resulting from dopamine extravasation. No adverse effects were noted except mild episodes of decreased blood pressure in two of the patients.

Publication types

  • Case Reports

MeSH terms

  • Administration, Topical
  • Catheters, Indwelling / adverse effects
  • Dopamine / administration & dosage
  • Dopamine / adverse effects
  • Extravasation of Diagnostic and Therapeutic Materials / complications
  • Hand / blood supply*
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Premature
  • Ischemia / drug therapy*
  • Ischemia / etiology
  • Nitroglycerin / administration & dosage*
  • Ointments


  • Ointments
  • Nitroglycerin
  • Dopamine