Stimulation of healing by free radical scavengers of ischemia-induced acute gastric mucosal injury in the rat

J Pharm Sci. 1992 Nov;81(11):1095-7. doi: 10.1002/jps.2600811111.

Abstract

Allopurinol and dimethyl sulfoxide (DMSO; 1 mL of 1, 2, or 5% by gavage daily) were used to examine the influence of scavenging oxygen-derived free radicals on the healing of reserpine- (5 mg/kg, intraperitoneal) and 5-hydroxytryptamine- (50 mg/kg, intraperitoneal) induced acute ischemic injury of the rat gastric mucosa. Allopurinol and DMSO demonstrated a time- but not dose-dependent power to stimulate healing of this injury. The magnitude of injury produced by reserpine or 5-hydroxytryptamine (serotonin) followed by gavage with allopurinol or DMSO was significantly (p < 0.01) less after day 4 than that after day 3 of this gavage, and the magnitude after day 3 was itself significantly (reserpine, p < 0.001; 5-hydroxytryptamine, p < 0.01) less than that after day 2 of the same gavage. The actions of allopurinol and DMSO were not associated with any significant influence on H+ output. These results suggest that oxygen-derived free radicals are detrimental to the integrity of the rat gastric mucosa and that scavenging them stimulates healing of the ischemia-induced injury of the mentioned mucosa.

MeSH terms

  • Allopurinol / therapeutic use*
  • Animals
  • Dimethyl Sulfoxide / therapeutic use*
  • Female
  • Free Radical Scavengers*
  • Intestinal Mucosa / blood supply*
  • Intestinal Mucosa / drug effects
  • Intestinal Mucosa / physiology
  • Ischemia / chemically induced
  • Ischemia / drug therapy*
  • Male
  • Rats
  • Rats, Sprague-Dawley
  • Reserpine
  • Serotonin

Substances

  • Free Radical Scavengers
  • Serotonin
  • Allopurinol
  • Reserpine
  • Dimethyl Sulfoxide