Synthesis and serotonergic pharmacology of the enantiomers of 3-[(N-methylpyrrolidin-2-yl)methyl]-5-methoxy-1H-indole: discovery of stereogenic differentiation in the aminoethyl side chain of the neurotransmitter serotonin

J Med Chem. 1992 Nov 13;35(23):4503-5. doi: 10.1021/jm00101a032.

Authors

J E Macor¹, J Blake, C B Fox, C Johnson, B K Koe, L A Lebel, J M Morrone, K Ryan, A W Schmidt, D W Schulz, et al.

Affiliation

¹ Department of Medicinal Chemistry, Pfizer, Inc, Groton, Connecticut 06340.

PMID: 1447752
DOI: 10.1021/jm00101a032

No abstract available

MeSH terms

Indoles / chemical synthesis*
Indoles / pharmacology
Pyrrolidines / chemical synthesis*
Pyrrolidines / pharmacology
Receptors, Serotonin / drug effects
Receptors, Serotonin / metabolism
Serotonin / metabolism
Serotonin Receptor Agonists / chemical synthesis*
Serotonin Receptor Agonists / pharmacology
Stereoisomerism

Substances

Indoles
Pyrrolidines
Receptors, Serotonin
Serotonin Receptor Agonists
Serotonin